Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory–Motor Synapses in Aplysia

@article{Sutton2000ParallelMP,
  title={Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory–Motor Synapses in Aplysia},
  author={Michael A Sutton and Thomas J. Carew},
  journal={Neuron},
  year={2000},
  volume={26},
  pages={219-231}
}
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Activity-dependent inhibitory gating in molecular signaling cascades induces a novel form of intermediate-term synaptic facilitation in Aplysia californica.
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Data support the hypothesis that sensory neuron activity coincident with the last RT training trial is sufficient to convert the molecular signaling already established by RT training into an AD-like molecular phenotype.
Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia I: Intermediate-Term Memory1
TLDR
This work has incorporated the temporal and molecular features of these different forms of ITF at tail SN-MN synapses into behavioral analyses, and found that they accurately predict distinct forms of intermediate-term memory for sensitization of the tail-elicited siphon withdrawal reflex.
Coincident Induction of Long-Term Facilitation at Sensory-Motor Synapses in Aplysia: Presynaptic and Postsynaptic Factors
TLDR
If Aplysia sensory neuron (SN) somata and their remote motor neuron (MN) synapses are simultaneously exposed to serotonin (5HT) pulses, processes activated at these sites interact to induce LTF, which differs mechanistically from coincident LTF.
Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia
Temporal Phases of Activity-Dependent Plasticity and Memory Are Mediated by Compartmentalized Routing of MAPK Signaling in Aplysia Sensory Neurons
Parallel somatic and synaptic processing in the induction of intermediate-term and long-term synaptic facilitation in Aplysia.
  • C. M. Sherff, T. Carew
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
The findings show that different temporal and spatial patterns of 5-HT induce specific temporal phases of long-lasting facilitation in parallel by engaging different cellular and molecular mechanisms.
Presynaptic Activation of Silent Synapses and Growth of New Synapses Contribute to Intermediate and Long-Term Facilitation in Aplysia
Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia
TLDR
It is shown that synaptic MAPK activation during TNS is required for the induction of intermediate-term synaptic facilitation, which leads to the persistent synaptic PKA activation required to maintain this facilitation.
Ca2+-Independent Protein Kinase C Apl II Mediates the Serotonin-Induced Facilitation at Depressed AplysiaSensorimotor Synapses
TLDR
The results demonstrate that short-term facilitation of depressed synapses is mediated by PKC Apl II and suggest that not only different signal transduction pathways but also different isoforms of a specific cascade may mediate physiological responses according to the state of a synapse.
Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia II: Long-Term Facilitation1
TLDR
The results show that two anatomically remote cellular compartments can functionally interact within a surprisingly short time period and that there are multiple forms of both ITF and LTF that differ in their induction and expression requirements, and at least in some instances, the different temporal phases of facilitation, and perhaps comparable phases of memory, can be induced independently of each other.
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IN both vertebrates and invertebrates, long-term memory differs from short-term in requiring protein synthesis during training1,2. Studies of the gill and siphon withdrawal reflex in Aplysia indicate…
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