Parallel Evolution of Streptococcus pneumoniae and Streptococcus mitis to Pathogenic and Mutualistic Lifestyles

@inproceedings{Kilian2014ParallelEO,
  title={Parallel Evolution of Streptococcus pneumoniae and Streptococcus mitis to Pathogenic and Mutualistic Lifestyles},
  author={Mogens Kilian and David R. Riley and Anders Bisgaard Jensen and Holger Br{\"u}ggemann and Herv{\'e} Tettelin},
  booktitle={mBio},
  year={2014}
}
The bacterium Streptococcus pneumoniae is one of the leading causes of fatal infections affecting humans. Intriguingly, phylogenetic analysis shows that the species constitutes one evolutionary lineage in a cluster of the otherwise commensal Streptococcus mitis strains, with which humans live in harmony. In a comparative analysis of 35 genomes, including phylogenetic analyses of all predicted genes, we have shown that the pathogenic pneumococcus has evolved into a master of genomic flexibility… CONTINUE READING
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