Paralemniscal TIP39 is induced in rat dams and may participate in maternal functions
@article{Varga2011ParalemniscalTI, title={Paralemniscal TIP39 is induced in rat dams and may participate in maternal functions}, author={Tam{\'a}s Varga and Bence Mogyor{\'o}di and Attila G Bago and Melinda Cserven{\'a}k and Dominika Domokos and {\'E}va Renner and Katalin Gallatz and Ted B Usdin and Mikl{\'o}s Palkovits and {\'A}rp{\'a}d Dobolyi}, journal={Brain Structure and Function}, year={2011}, volume={217}, pages={323 - 335} }
The paralemniscal area, situated between the pontine reticular formation and the lateral lemniscus in the pontomesencephalic tegmentum contains some tuberoinfundibular peptide of 39 residues (TIP39)-expressing neurons. In the present study, we measured a 4 times increase in the level of TIP39 mRNA in the paralemniscal area of lactating mothers as opposed to nulliparous females and mothers deprived of pups using real-time RT-PCR. In situ hybridization histochemistry and immunolabeling…
16 Citations
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The structure of PTH2R bound to its endogenous ligand, tuberoinfundibular peptide (TIP39), and a heterotrimeric Gs protein reveals that TIP39 adopts a unique loop conformation at the N terminus and deeply inserts into the orthosteric ligand-binding pocket in the transmembrane domain, which provides structural insights into ligand specificity and receptor activation of class B1 GPCRs.
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