Paralemniscal TIP39 is induced in rat dams and may participate in maternal functions

@article{Varga2011ParalemniscalTI,
  title={Paralemniscal TIP39 is induced in rat dams and may participate in maternal functions},
  author={Tam{\'a}s Varga and Bence Mogyor{\'o}di and Attila G. Bag{\'o} and Melinda Cserven{\'a}k and Dominika Domokos and {\'E}va Renner and Katalin Gallatz and Ted B Usdin and Mikl{\'o}s Palkovits and {\'A}rp{\'a}d Dobolyi},
  journal={Brain Structure and Function},
  year={2011},
  volume={217},
  pages={323-335}
}
The paralemniscal area, situated between the pontine reticular formation and the lateral lemniscus in the pontomesencephalic tegmentum contains some tuberoinfundibular peptide of 39 residues (TIP39)-expressing neurons. In the present study, we measured a 4 times increase in the level of TIP39 mRNA in the paralemniscal area of lactating mothers as opposed to nulliparous females and mothers deprived of pups using real-time RT-PCR. In situ hybridization histochemistry and immunolabeling… Expand
View on Springer
europepmc.org
15 Citations
Highly Influential Citations
1
Background Citations
3

15 Citations

Citation Type

Citation Type

Preoptic Inputs and Mechanisms that Regulate Maternal Responsiveness
TLDR
The idea that chromatin remodelling during mother–infant interactions mediates the long‐term alterations in gene expression that sustain maternal responding is explored and summarise gene expression changes in the mPOA that have been linked to maternal behaviour. Expand
Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation
TLDR
It is found that TIP39 mRNA levels in the PIL markedly increased around parturition and remained elevated throughout the lactation period, demonstrating the availability of the peptide in postpartum mothers. Expand
A Thalamo-Hypothalamic Pathway That Activates Oxytocin Neurons in Social Contexts in Female Rats
TLDR
Neurons in the posterior intralaminar complex of the thalamus (PIL), which contain tuberoinfundibular peptide 39 (TIP39) and are activated by pup exposure in lactating mothers, provide a candidate projection that contributes to the activation of oxytocin neurons in social contexts. Expand
Thalamic integration of social stimuli regulating parental behavior and the oxytocin system
TLDR
The present review argues that the PIL is a major relay nucleus conveying somatosensory information supporting maternal behavior and oxytocin release in mothers, and may be involved more generally in social cue evoked oxytocIn release, too. Expand
Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats.
TLDR
Findings suggest the suckling-induced activation of SST-SSTR2 signaling mediates, at least in part, the suppression of pulsatile LH secretion during lactation in rats, probably via the indirect effects of S ST on KNDy neurons. Expand
Neuroendocrine regulation of lactation and milk production.
TLDR
The reduction in secretion of the adipocyte hormone, leptin, a hallmark of negative energy balance, may be an important endocrine signal to hypothalamic systems that integrate lactation-associated food intake with neuroendocrine systems. Expand
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
  • Xi Wang, Xi Cheng, +12 authors Ming-Wei Wang
  • Medicine
  • Proceedings of the National Academy of Sciences
  • 2021
TLDR
The structure of PTH2R bound to its endogenous ligand, tuberoinfundibular peptide (TIP39), and a heterotrimeric Gs protein reveals that TIP39 adopts a unique loop conformation at the N terminus and deeply inserts into the orthosteric ligand-binding pocket in the transmembrane domain, which provides structural insights into ligand specificity and receptor activation of class B1 GPCRs. Expand
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
TLDR
The cryo-electron microscopy structure of PTH2R bound to its endogenous ligand, tuberoinfundibular peptide (TIP39), and a heterotrimeric Gs protein is reported, revealing that TIP39 adopts a unique loop conformation at N terminus and deeply inserts into the orthosteric ligand-binding pocket in the transmembrane (TM) domain. Expand
Tuberoinfundibular peptide of 39 amino acids
A tuberoinfundibuláris peptid 39 és a kettes típusú parathormon receptor neuromodulátor rendszer szerepe az anyai adaptációk központi idegrendszeri szabályozásában
...
1
2
...

References

SHOWING 1-10 OF 57 REFERENCES
Putative nociceptive modulatory neurons in the dorsolateral pontomesencephalic reticular formation
TLDR
On- and off-cells were found throughout the region from which TF suppression was observed but were most concentrated in the areas of the NCF and NPB, which suggests that the input to RVM from NCF/NPB may be important in descending nociceptive modulation. Expand
The medial paralemniscal nucleus and its afferent neuronal connections in rat
TLDR
The afferent neuronal connections of the MPL suggest its involvement in auditory and reproductive functions and is characterized cytoarchitectonically on coronal, sagittal, and horizontal serial sections. Expand
Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception
TLDR
The data suggest that TIP39 signaling modulates nociception, very likely by inhibiting endocannabinoid circuitry at a supraspinal level, and infer a new central mechanism for endoc cannabinoidoid regulation, via TIP 39 acting on the PTH2R in discrete brain regions. Expand
Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception
TLDR
The data suggest that TIP39 released from supraspinal fibers potentiates aspects of nociception within the spinal cord. Expand
Periaqueductal gray and the region of the paralemniscal area have different functions in the control of vocalization in the neotropical bat, Phyllostomus discolor
TLDR
Periaqueductal gray and paralemniscal area interact differently with the final common pathway for vocalization, and may represent different functional organization in the vocal controlling pathways for communication calls and echolocation calls. Expand
Postnatal development and gender‐dependent expression of TIP39 in the rat brain
TLDR
Investigation of the expression of TIP39 and the PTH2 receptor in male and female rat brain during postnatal development by means of in situ hybridization histochemistry, quantitative RT‐PCR, and immunocytochemistry suggests that TIP 39 may play a role in sexual maturation or gender‐specific functions. Expand
Afferent connections of the parvocellular subparafascicular thalamic nucleus in the rat: Evidence for functional subdivisions
TLDR
The hypothesis that medial and lateral subdivisions of SPFp receive different sets of afferents and that these differences contribute to the separate functional roles of the two subdivisions is tested. Expand
Localization and Chemical Characterization of the Audiogenic Stress Pathway
TLDR
It has been shown by immunostaining that TIP39‐containing MPL and SPF neurons express a newly discovered neuropeptide, tuberoinfundibular peptide of 39 residues (TIP39), which is present in a fine neuronal network in the PVN. Expand
Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic–pituitary–adrenal axis via paraventricular glutamatergic neurons
TLDR
The present data indicate that the TIP39 ligand/PTH2 receptor system provides facilitatory regulation of the hypothalamic–pituitary–adrenal axis via hypothalamic glutamatergic neurons and that it may regulate other neuroendocrine systems by a similar mechanism. Expand
Neurons containing tuberoinfundibular peptide of 39 residues project to limbic, endocrine, auditory and spinal areas in rat
TLDR
The projections of the TIP39-containing cells in the subparafascicular area suggest their involvement in limbic and endocrine functions, while the projections of those in the medial paralemniscal nucleus suggest their involved in auditory and nociceptive functions. Expand
...
1
2
3
4
5
...