Paralemniscal TIP39 is induced in rat dams and may participate in maternal functions

@article{Varga2011ParalemniscalTI,
  title={Paralemniscal TIP39 is induced in rat dams and may participate in maternal functions},
  author={Tam{\'a}s Varga and Bence Mogyor{\'o}di and Attila G. Bag{\'o} and Melinda Cserven{\'a}k and Dominika Domokos and {\'E}va Renner and Katalin Gallatz and Ted B Usdin and Mikl{\'o}s Palkovits and {\'A}rp{\'a}d Dobolyi},
  journal={Brain Structure and Function},
  year={2011},
  volume={217},
  pages={323-335}
}
The paralemniscal area, situated between the pontine reticular formation and the lateral lemniscus in the pontomesencephalic tegmentum contains some tuberoinfundibular peptide of 39 residues (TIP39)-expressing neurons. In the present study, we measured a 4 times increase in the level of TIP39 mRNA in the paralemniscal area of lactating mothers as opposed to nulliparous females and mothers deprived of pups using real-time RT-PCR. In situ hybridization histochemistry and immunolabeling… Expand
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Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
  • Xi Wang, Xi Cheng, +12 authors Ming-Wei Wang
  • Medicine
  • Proceedings of the National Academy of Sciences
  • 2021
TLDR
The structure of PTH2R bound to its endogenous ligand, tuberoinfundibular peptide (TIP39), and a heterotrimeric Gs protein reveals that TIP39 adopts a unique loop conformation at the N terminus and deeply inserts into the orthosteric ligand-binding pocket in the transmembrane domain, which provides structural insights into ligand specificity and receptor activation of class B1 GPCRs. Expand
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
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The cryo-electron microscopy structure of PTH2R bound to its endogenous ligand, tuberoinfundibular peptide (TIP39), and a heterotrimeric Gs protein is reported, revealing that TIP39 adopts a unique loop conformation at N terminus and deeply inserts into the orthosteric ligand-binding pocket in the transmembrane (TM) domain. Expand
Tuberoinfundibular peptide of 39 amino acids
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