Parakeratosis in skin is associated with loss of inhibitor of differentiation 4 via promoter methylation.

@article{Ruchusatsawat2011ParakeratosisIS,
  title={Parakeratosis in skin is associated with loss of inhibitor of differentiation 4 via promoter methylation.},
  author={Kriangsak Ruchusatsawat and Jongkonnee Wongpiyabovorn and Phantipa Protjaroen and Mookda Chaipipat and Shanop Shuangshoti and Paul Scott Thorner and Apiwat Mutirangura},
  journal={Human pathology},
  year={2011},
  volume={42 12},
  pages={1878-87}
}
Parakeratosis refers to incomplete maturation of epidermal keratinocytes, resulting in abnormal retention of nuclei in the stratum corneum. It occurs in many diseases of the skin, particularly in psoriasis. Down-regulation of inhibitor of differentiation 4 messenger RNA has been demonstrated in psoriatic skin, but the specificity and mechanism for this finding are unknown. In this study, we addressed specificity by immunohistochemical staining for inhibitor of differentiation 4 protein in skin… CONTINUE READING

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