Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries.

  title={Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries.},
  author={P L Ludmer and Andrew P Selwyn and Thomas L. Shook and R. Rush Wayne and Gilbert H. Mudge and Robert W. Alexander and Peter A Ganz},
  journal={The New England journal of medicine},
  volume={315 17},
Acetylcholine is believed to dilate normal blood vessels by promoting the release of a vasorelaxant substance from the endothelium (endothelium-derived relaxing factor). By contrast, if the endothelium is removed experimentally, acetylcholine constricts blood vessels. We tested the hypothesis that muscarinic cholinergic vasodilation is impaired in coronary atherosclerosis. Graded concentrations of acetylcholine and, for comparison, the nonendothelial-dependent vasodilator nitroglycerin were… CONTINUE READING
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