Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists

@article{Gray2001ParadoxicalTA,
  title={Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists},
  author={J. Gray and B. Roth},
  journal={Brain Research Bulletin},
  year={2001},
  volume={56},
  pages={441-451}
}
  • J. Gray, B. Roth
  • Published 2001
  • Psychology, Medicine
  • Brain Research Bulletin
5-Hydroxytryptamine(2A) (serotonin(2A), 5-HT(2A)) receptors are important for many physiologic processes including platelet aggregation, smooth muscle contraction, and the modulation of mood and perception. A large number of pharmaceutical agents mediate their actions, at least in part, by modulating the number and/or activity of 5-HT(2A) receptors. Drugs with action at 5-HT(2A) receptors are used in the treatment of many disorders, including schizophrenia, depression, and anxiety disorders… Expand
258 Citations
Serotonin receptors involved in antidepressant effects.
  • 217
  • PDF
Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo
  • 152
  • PDF
Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?
  • 63
Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse.
  • 121
Identification of two serine residues essential for agonist-induced 5-HT2A receptor desensitization.
  • 45
  • PDF
Differential regulation of rat peripheral 5-HT2A and 5-HT2B receptor systems: influence of drug treatment
  • 12
The therapeutic role of 5-HT1A and 5-HT2A receptors in depression.
  • 405
Serotonin receptor signaling and regulation via β-arrestins
  • 33
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 122 REFERENCES
5‐HT2 Receptors, Roles and Regulation
  • 71
Regulation of 5-HT2 and 5-HT1C serotonin receptor levels. Methodology and mechanisms.
  • B. Roth, M. Hamblin, R. Ciaranello
  • Biology, Medicine
  • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
  • 1990
  • 44
Effects of agonists, partial agonists, and antagonists on the regulation of 5-hydroxytryptamine2 receptors in P11 cells.
  • 36
Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation.
  • 110
Antagonist-mediated down-regulation of 5-hydroxytryptamine type 2 receptor gene expression: modulation of transcription.
  • 54
Gaps and peculiarities in 5-HT2 receptor studies.
  • J. Leysen
  • Chemistry, Medicine
  • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
  • 1990
  • 55
Rapid desensitization and down-regulation of 5-HT2 receptors by DOM treatment.
  • 102
  • PDF
Distinct Mechanisms Regulate 5-HT2 and Thrombin Receptor Desensitization (*)
  • 61
  • PDF
...
1
2
3
4
5
...