Paradoxical stimulation by amino acids of the degradation of [35S]methionine-labelled, short-lived protein in isolated rat hepatocytes.

Abstract

A complete amino acid mixture inhibited the degradation of long-lived and [14C]valine-labelled short-lived protein in isolated rat hepatocytes, but paradoxically stimulated the degradation of [35S]methionine-labelled short-lived protein. The stimulation persisted in the presence of autophagiclysosomal pathway inhibitors like 3-methyladenine and propylamine… (More)

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