Paradoxical roles of the immune system during cancer development

@article{Visser2006ParadoxicalRO,
  title={Paradoxical roles of the immune system during cancer development},
  author={Karin E. de Visser and Alexandra Eichten and Lisa M. Coussens},
  journal={Nature Reviews Cancer},
  year={2006},
  volume={6},
  pages={24-37}
}
The main function of the mammalian immune system is to monitor tissue homeostasis, to protect against invading or infectious pathogens and to eliminate damaged cells. Therefore, it is surprising that cancer occurs with such a high frequency in humans. Recent insights that have been gained from clinical studies and experimental mouse models of carcinogenesis expand our understanding of the complex relationship between immune cells and developing tumours. Here, we examine the paradoxical role of… 

Oncogenic stress sensed by the immune system: role of natural killer cell receptors

TLDR
This Review addresses the current understanding of the mechanisms that detect cellular stresses that are associated with tumorigenesis and that culminate in the recognition and, in some cases, the elimination of the tumour cells by natural killer cells and other lymphocytes that express natural killer cell receptors.

Nod-Like Receptors: Key Molecular Switches in the Conundrum of Cancer

TLDR
All the current evidence for NLR involvement in the different stages of neoplasia is presented to understand how a single molecular pathway can contribute to conflicting immunological interactions with cancer.

Tumor progression mechanisms: Insights from the central immune regulation of tissue homeostasis

TLDR
The functional features of the immune system that contribute to the maintenance of normal tissue homeostasis, as well as their disruption in malignant transformations, were analyzed and may provide an insight into cancer evolution in terms of the mechanisms of T-cell competency formation.

Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression

TLDR
Important new findings revealing the paradoxical role of innate and adaptive leukocytes as regulators of breast carcinogenesis are summarized.

Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment

TLDR
Defining the complex network of interactions and crosstalk of ILC with other immune cells and understanding the specific contributions of each type of I LC leading to tumor development will allow the manipulation of their function and will be important to develop new interventions and therapeutic strategies.

Immunosurveillance of cancer cell stress

TLDR
How distinct situations of cellular stress influence innate and adaptive immunity and the consequent impact on cancer establishment and progression is explored.

Complementing the tumor-specific immunity in tumor radiotherapy.

The role of immune system and inflammation in tumor development has recently rekindled the attention of researchers and Douglas Hanahan and Robert A. Weinberg have listed them to one of the ten

Immune surveillance: a balance between protumor and antitumor immunity.

Spontaneous immune responses to sporadic tumors: tumor-promoting, tumor-protective or both?

TLDR
The role of the dynamic inflammatory tumor microenvironment during cancer development and progression is discussed, and the intriguing question: "Do malignancies develop in spite of-or because of-spontaneous immune responses?" is focused on.

Utilizing Mouse Models of Human Cancer for Assessing Immune Modulation of Cancer Development

TLDR
relevant literature is reviewed, where mouse models of human cancer development have provided novel insights into mechanisms of pro- versus antitumor immunity.
...

References

SHOWING 1-10 OF 139 REFERENCES

Immunosuppressive networks in the tumour environment and their therapeutic relevance

  • W. Zou
  • Medicine, Biology
    Nature Reviews Cancer
  • 2005
It is well known that many tumours are potentially immunogenic, as corroborated by the presence of tumour-specific immune responses in vivo. Nonetheless, spontaneous clearance of established tumours

Derangement of immune responses by myeloid suppressor cells

TLDR
A review examines recent findings on the nature, properties, and mechanisms of action of these myeloid suppressor cells (MSCs) in tumor-bearing mice and cancer patients.

Where have all the T cells gone? Mechanisms of immune evasion by tumors.

Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer

TLDR
It is reported that aged granulocyte-macrophage colony stimulating factor-deficient mice develop a systemic lupus erythematosis (SLE)-like disorder associated with the impaired phagocytosis of apoptotic cells, demonstrating that the interplay of infectious agents with cytokine-mediated regulation of immune homeostasis is a critical determinant of cancer susceptibility.

Breaking tolerance in cancer immunotherapy: time to ACT.

  • W. Overwijk
  • Biology, Medicine
    Current opinion in immunology
  • 2005

Close encounters of different kinds: Dendritic cells and NK cells take centre stage

TLDR
Dendritic cells, long recognized as key initiators of primary adaptive immunity, are now also seen as crucial regulators of aspects of innate immunity, in particular natural-killer-cell function.

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

TLDR
Sp spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF) is described.

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

TLDR
It is shown that lymphocytes and IFNγ collaborate to protect against development of carcinogen-induced sarcomas and spontaneous epithelial carcinomas and also to select for tumour cells with reduced immunogenicity, which explains the apparent paradox of tumour formation in immunologically intact individuals.

Natural resistance mechanisms may play a role in protection against chemical carcinogenesis

TLDR
Experiments indicate that the latent period of primary tumors induced by the injection of methylcholanthrene is also prolonged in these mice, suggesting that NR mechanisms may provide protection against primary chemically induced tumors.
...