Paradoxical roles of the immune system during cancer development

  title={Paradoxical roles of the immune system during cancer development},
  author={Karin E. de Visser and Alexandra Eichten and Lisa M. Coussens},
  journal={Nature Reviews Cancer},
The main function of the mammalian immune system is to monitor tissue homeostasis, to protect against invading or infectious pathogens and to eliminate damaged cells. Therefore, it is surprising that cancer occurs with such a high frequency in humans. Recent insights that have been gained from clinical studies and experimental mouse models of carcinogenesis expand our understanding of the complex relationship between immune cells and developing tumours. Here, we examine the paradoxical role of… 

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A review examines recent findings on the nature, properties, and mechanisms of action of these myeloid suppressor cells (MSCs) in tumor-bearing mice and cancer patients.

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Dendritic cells, long recognized as key initiators of primary adaptive immunity, are now also seen as crucial regulators of aspects of innate immunity, in particular natural-killer-cell function.

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