Paradoxical resistance to diet-induced obesity in UCP1-deficient mice.

  title={Paradoxical resistance to diet-induced obesity in UCP1-deficient mice.},
  author={Xiaotuan Liu and Martin Rossmeisl and Jennifer W McClaine and Mark Riachi and M H Harper and Leslie Paul Kozak},
  journal={The Journal of clinical investigation},
  volume={111 3},
The availability of mice lacking the mitochondrial uncoupling protein UCP1, has provided an opportunity to analyze the relationship between the capacity for energy expenditure and the development of obesity in response to a high-fat, high-sucrose diet. Congenic UCP1-deficient mice on a C57BL/6J genetic background show a temperature-dependent resistance to diet-induced obesity when compared with wild-type mice. This resistance, which occurs at 20 degrees C, is quickly reversed when the ambient… CONTINUE READING
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