Paradoxical impact of cholesterol on lipid packing and cell stiffness.

@article{Ayee2016ParadoxicalIO,
  title={Paradoxical impact of cholesterol on lipid packing and cell stiffness.},
  author={M. A. Ayee and I. Levitan},
  journal={Frontiers in bioscience},
  year={2016},
  volume={21},
  pages={
          1245-59
        }
}
Cell stiffness or deformability is a fundamental property that is expected to play a major role in multiple cellular functions. It is well known that cell stiffness is dominated by the intracellular cytoskeleton that, together with the plasma membrane, forms a membrane-cytoskeleton envelope. However, our understanding of how lipid composition of plasma membrane regulates physical properties of the underlying cytoskeleton is only starting to emerge. In this review, we first briefly describe the… Expand
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