Paradoxical hyperfibrinolysis is associated with a more intensely haemorrhagic phenotype in severe congenital haemophilia.

@article{Gruenewald2002ParadoxicalHI,
  title={Paradoxical hyperfibrinolysis is associated with a more intensely haemorrhagic phenotype in severe congenital haemophilia.},
  author={Martin Gruenewald and Annelie Siegemund and Anja Gr{\"u}newald and A Konegan and Mario Koksch and Martin Griesshammer},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  year={2002},
  volume={8 6},
  pages={
          768-75
        }
}
To elucidate potential causes for differing bleeding phenotypes of haemophilic patients of identical degree of coagulation factor deficiency, we investigated 21 male patients with severe haemophilia. Median annual coagulation factor demand and the extent of haemophilic arthropathy were used to discriminate between intensely and less intensely haemorrhagic phenotypes. Haemophiliacs with a median annual coagulation factor demand of 800 IU per kg bodyweight or more and with three or more joints… CONTINUE READING

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