Paradoxical growth effect of caspofungin observed on biofilms and planktonic cells of five different Candida species.

@article{Melo2007ParadoxicalGE,
  title={Paradoxical growth effect of caspofungin observed on biofilms and planktonic cells of five different Candida species.},
  author={Analy Salles de Azevedo Melo and Arnaldo Lopes Colombo and Beth A. Arthington-Skaggs},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 9},
  pages={3081-8}
}
The paradoxical growth (PG) of Candida sp. biofilms in the presence of high caspofungin (CAS) concentrations was previously unknown. We sought to characterize the PG at supra-MICs of CAS among clinical Candida sp. isolates grown as biofilms in 96-well polystyrene microtiter plates. The MICs of CAS were determined for 30 clinical Candida sp. isolates (4 Candida albicans, 6 C. tropicalis, 7 C. parapsilosis, 8 C. orthopsilosis, and 5 C. metapsilosis isolates) when they were grown as planktonic… CONTINUE READING