Paradoxical fear-increasing effects of tranquilizers: evidence of repression of memory in the rat.

@article{Stein1969ParadoxicalFE,
  title={Paradoxical fear-increasing effects of tranquilizers: evidence of repression of memory in the rat.},
  author={Larry Stein and Barry D. Berger},
  journal={Science},
  year={1969},
  volume={166 3902},
  pages={253-6}
}
Conditioned suppression of feeding, an index of fear, was increased rather than decreased by the administration of benzodiazepine tranquilizers or amobarbital. The drug-induced increase in conditioned fear varied directly with the intensity of the shock used in fear conditioning. The drugs had no fear-increasing effect in unshocked controls or in rats made amnesic by electroconvulsive shock given immediately after fear conditioning. These observations in animals are reminiscent of clinical… CONTINUE READING