Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice.

@article{Lyons2002ParadoxicalEO,
  title={Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice.},
  author={Malcolm A. Lyons and Nobuyo N. Maeda and Andrew J Brown},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1581 3},
  pages={119-26}
}
7-Ketocholesterol (7KC) is a major oxysterol found in atherosclerotic plaque and is believed to be derived both endogenously and exogenously (from the diet). Previously, we have demonstrated that subsequent to hepatic lipoprotein uptake, 7KC delivered in a model chylomicron remnant lipid emulsion is metabolised more rapidly and excreted into the intestinal tract and faeces to a much greater extent than simultaneously administered cholesterol. Furthermore, we have shown that human 7KC metabolism… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
Previously , we have demonstrated that subsequent to hepatic lipoprotein uptake , 7KC delivered in a model chylomicron remnant lipid emulsion is metabolised more rapidly and excreted into the intestinal tract and faeces to a much greater extent than simultaneously administered cholesterol .
Previously , we have demonstrated that subsequent to hepatic lipoprotein uptake , 7KC delivered in a model chylomicron remnant lipid emulsion is metabolised more rapidly and excreted into the intestinal tract and faeces to a much greater extent than simultaneously administered cholesterol .
All Topics