Paradoxical enhancement of active cochlear mechanics in long-term administration of salicylate.

  title={Paradoxical enhancement of active cochlear mechanics in long-term administration of salicylate.},
  author={Zhi-wu Huang and Yanyun Luo and Zhanyuan Wu and Zhezhang Tao and Raleigh O Jones and H Zhao},
  journal={Journal of neurophysiology},
  volume={93 4},
Aspirin (salicylate) is a common drug and frequently used long term in the clinic. It has been well documented that salicylate can cause reversible hearing loss and tinnitus and diminish outer hair cell (OHC) electromotility, which is capable of actively boosting the basilar membrane vibration and producing acoustic emission. However, aspirin's ototoxic mechanisms still remain largely unclear. In this experiment, the effects of long-term salicylate administration on cochlear hearing functions… CONTINUE READING


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