Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain.

Abstract

OBJECTIVE The present study examined whether local administration of the cannabinoid-2 (CB(2)) receptor agonist GW405833 could modulate joint nociception in control rat knee joints and in an animal model of osteoarthritis (OA). METHOD OA was induced in male Wistar rats by intra-articular injection of sodium monoiodo-acetate with a recovery period of 14… (More)
DOI: 10.1016/j.joca.2010.09.005

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