Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.

@article{Chefer2006ParadoxicalEO,
  title={Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens.},
  author={Vladimir I. Chefer and Toni Shaun Shippenberg},
  journal={The European journal of neuroscience},
  year={2006},
  volume={23 1},
  pages={
          229-38
        }
}
Quantitative and conventional microdialysis were used to investigate the effects of constitutive deletion of the prodynorphin gene on basal dopamine (DA) dynamics in the nucleus accumbens (NAc) and the responsiveness of DA neurons to an acute cocaine challenge. Saline- and cocaine-evoked locomotor activity were also assessed. Quantitative microdialysis revealed that basal extracellular DA levels were decreased, while the DA extraction fraction, an indirect measure of DA uptake, was unchanged in… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Supersensitivity to Amphetamine in Protein Kinase-C Interacting Protein/HINT1 Knockout Mice

Neuropsychopharmacology • 2007
View 6 Excerpts
Method Support
Highly Influenced