Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation.

@article{Min2004ParadoxicalEO,
  title={Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation.},
  author={Chang-Ki Min and Yoshinobu Maeda and Kathleen P. Lowler and Chen Liu and Shawn G. Clouthier and David M Lofthus and Elizabeth Weisiger and James L. M. Ferrara and Pavan Reddy},
  journal={Blood},
  year={2004},
  volume={104 10},
  pages={3393-9}
}
Administration of exogenous interleukin-18 (IL-18) regulates experimental acute graft-versus-host disease (GVHD) in a Fas-dependent manner when donor CD4(+) T cells are required for mortality after experimental allogeneic bone marrow transplantation (BMT). However, CD4(+) and CD8(+) T cells can induce acute GVHD after clinical allogeneic BMT, and the role of IL-18 in CD8(+)-mediated acute GVHD is unknown. We, therefore, determined the role of IL-18 in GVHD mediated by CD4(+) or CD8(+) T cells… CONTINUE READING
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