Paradoxical effects of constitutive human IL-32{gamma} in transgenic mice during experimental colitis.

@article{Choi2010ParadoxicalEO,
  title={Paradoxical effects of constitutive human IL-32\{gamma\} in transgenic mice during experimental colitis.},
  author={Jida Choi and Suyoung Bae and Jaewoo Hong and Soyoon Ryoo and Hyunjhung Jhun and Kwangwon Hong and Doyoung Yoon and Siyoung Lee and Erk Her and Wonhyuk Choi and Jeonghwan Kim and Tania Azam and Charles A Dinarello and Soohyun Kim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 49},
  pages={
          21082-6
        }
}
Inflammatory cytokines mediate inflammatory bowel diseases (IBDs) and cytokine blocking therapies often ameliorate the disease severity. IL-32 affects inflammation by increasing the production of IL-1, TNFα, and several chemokines. Here, we investigated the role of IL-32 in intestinal inflammation by generating a transgenic (TG) mouse expressing human IL-32γ (IL-32γ TG). Although IL-32γ TG mice are healthy, constitutive serum and colonic tissue levels of TNFα are elevated. Compared with wild… CONTINUE READING

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