Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons

  title={Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons},
  author={T. B{\"a}ckstr{\"o}m and D. Haage and M. L{\"o}fgren and I. Johansson and S. K. Bengtsson},
  • T. Bäckström, D. Haage, +2 authors S. K. Bengtsson
  • Published 2011
  • Psychology, Medicine, Chemistry
  • Neuroscience
  • Some women have negative mood symptoms, caused by progestagens in hormonal contraceptives or sequential hormone therapy or by progesterone in the luteal phase of the menstrual cycle, which may be attributed to metabolites acting on the GABA-A receptor. The GABA system is the major inhibitory system in the adult CNS and most positive modulators of the GABA-A receptor (benzodiazepines, barbiturates, alcohol, GABA steroids), induce inhibitory (e.g. anesthetic, sedative, anticonvulsant, anxiolytic… CONTINUE READING
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