Paradoxical effect of three-day thymectomy on sarcogenesis in the mouse with different dosages of methylcholanthrene.

@article{Prehn1986ParadoxicalEO,
  title={Paradoxical effect of three-day thymectomy on sarcogenesis in the mouse with different dosages of methylcholanthrene.},
  author={Lillian M. Prehn and Akinori Kojima},
  journal={Cancer research},
  year={1986},
  volume={46 10},
  pages={4971-2}
}
Past studies have shown that thymectomy in the mouse at 3 days of age but not at birth or after 7 days produces, in later life, a variety of localized autoimmune lesions. In the present work, 3-day thymectomy facilitated subsequent sarcogenesis by low dosages of 3-methylcholanthrene but inhibited oncogenesis by a high dosage. If the presence of autoimmunity implies an increased antitumor immunity, it then follows that increased immunity facilitated low-dose sarcogenesis but inhibited… CONTINUE READING