Paradoxical down-regulation of p16INK4a mRNA with advancing age in Acute Myeloid Leukemia

Abstract

Aging is generally considered to be the consequence of stem cell attrition caused by the activity of tumor suppressor pathways that censor potentially malignant clones by eliciting apoptosis or senescence. An important effector of aging is the cyclindependent kinase inhibitor p16(INK4a), which is also a known suppressor of cancer. The expression of p16… (More)

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