Paradoxical convulsant action of a novel non-competitiveN-methyl-d-aspartate (NMDA) antagonist, tiletamine
@article{Klockgether1988ParadoxicalCA, title={Paradoxical convulsant action of a novel non-competitiveN-methyl-d-aspartate (NMDA) antagonist, tiletamine}, author={Thomas Klockgether and Lechosław Turski and Michael Schwarz and K-H. Sontag and John C. Lehmann}, journal={Brain Research}, year={1988}, volume={461}, pages={343-348} }
30 Citations
Non-competitive N-methyl-D-aspartate antagonists protect against sound-induced seizures in DBA/2 mice.
- Medicine, BiologyEuropean journal of pharmacology
- 1989
Differential effects of antiepileptic drugs and β-carbolines on seizures induced by excitatory amino acids
- Biology, PsychologyNeuroscience
- 1990
Effects of a non-competitive N-methyl-d-aspartate (NMDA) antagonist, tiletamine, in adult zebrafish.
- Biology, PsychologyNeurotoxicology and teratology
- 2017
Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy
- Biology, PsychologyBrain Research
- 1994
Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats.
- Biology, MedicineThe Indian journal of medical research
- 2004
The results suggested that excitatory neurotransmission contributed to the generation and/or propagation of Imi/Cil-induced seizures in rats, and that the effects of NMDA antagonists depended on a particular binding site within the NMDA receptor complex, and affinity to that site.
Anticonvulsant effects of the glycine/NMDA receptor ligands d‐cycloserine and d‐serine but not R‐(+)‐HA‐966 in amygdala‐kindled rats
- Biology, PsychologyBritish journal of pharmacology
- 1994
Pharmacological intervention at the strychnine‐insensitive glycine receptor by high‐efficacy partial agonists with systemic bioavailability may be an effective means of increasing seizure threshold without concomitantly inducing PCP‐like adverse effects.
Comparative analysis of seizures induced by intracerebroventricular administration of NMDA, kainate and quisqualate in mice
- Biology, MedicineExperimental Brain Research
- 2005
This study confirms that NMDA, KA and QA induce convulsions through different underlying mechanisms and suggests that different anatomical pathways are involved in these models.
Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats.
- BiologyEuropean journal of pharmacology
- 1995
High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats
- Biology, PsychologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 2004
It is demonstrated that kindled rats are more sensitive to central nervous system stimulating effects of memantine than non-kindled rats, which could relate to an impairment of inhibitory processes and/or alterations in synaptic transmission mediated by excitatory amino acids in the kindled brain.
Contrasting Neurochemical Interactions of Tiletamine, a Potent Phencyclidine (PCP) Receptor Ligand, with the N‐Methyl‐D‐Aspartate‐Coupled and ‐Uncoupled PCP Recognition Sites
- Biology, ChemistryJournal of neurochemistry
- 1991
The paradoxical effects of tiletamines suggest that tiletamine might activate receptor(s) or neuronal pathways of unknown pharmacology.
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