Paradoxical convulsant action of a novel non-competitiveN-methyl-d-aspartate (NMDA) antagonist, tiletamine

@article{Klockgether1988ParadoxicalCA,
  title={Paradoxical convulsant action of a novel non-competitiveN-methyl-d-aspartate (NMDA) antagonist, tiletamine},
  author={Thomas Klockgether and Lechosław Turski and Michael Schwarz and K-H. Sontag and John C. Lehmann},
  journal={Brain Research},
  year={1988},
  volume={461},
  pages={343-348}
}
View on Elsevier
doi.org
30 Citations
Background Citations
3
Results Citations
1

30 Citations

Differential effects of antiepileptic drugs and β-carbolines on seizures induced by excitatory amino acids

Effects of a non-competitive N-methyl-d-aspartate (NMDA) antagonist, tiletamine, in adult zebrafish.

Anticonvulsant activity of antagonists and partial agonists for the NMDA receptor-associated glycine site in the kindling model of epilepsy

Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats.

TLDR
The results suggested that excitatory neurotransmission contributed to the generation and/or propagation of Imi/Cil-induced seizures in rats, and that the effects of NMDA antagonists depended on a particular binding site within the NMDA receptor complex, and affinity to that site.

Anticonvulsant effects of the glycine/NMDA receptor ligands d‐cycloserine and d‐serine but not R‐(+)‐HA‐966 in amygdala‐kindled rats

TLDR
Pharmacological intervention at the strychnine‐insensitive glycine receptor by high‐efficacy partial agonists with systemic bioavailability may be an effective means of increasing seizure threshold without concomitantly inducing PCP‐like adverse effects.

Comparative analysis of seizures induced by intracerebroventricular administration of NMDA, kainate and quisqualate in mice

TLDR
This study confirms that NMDA, KA and QA induce convulsions through different underlying mechanisms and suggests that different anatomical pathways are involved in these models.

Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats.

High doses of memantine (1-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats

TLDR
It is demonstrated that kindled rats are more sensitive to central nervous system stimulating effects of memantine than non-kindled rats, which could relate to an impairment of inhibitory processes and/or alterations in synaptic transmission mediated by excitatory amino acids in the kindled brain.

Contrasting Neurochemical Interactions of Tiletamine, a Potent Phencyclidine (PCP) Receptor Ligand, with the N‐Methyl‐D‐Aspartate‐Coupled and ‐Uncoupled PCP Recognition Sites

TLDR
The paradoxical effects of tiletamines suggest that tiletamine might activate receptor(s) or neuronal pathways of unknown pharmacology.

Low Doses of the Glycine/NMDA Receptor Antagonist R‐(+)‐HA‐966 but not d‐Cycloserine Induce Paroxysmal Activity in Limbic Brain Regions of Kindled Rats

TLDR
The changes in electrographic recordings seen after administration of (+)‐HA‐966 in kindled rats were almost absent in non‐kindled rats, indicating that kindling had increased the sensitivity to the paroxysmal effects of the glycine/NMDA receptor ligand.

References

SHOWING 1-10 OF 21 REFERENCES

Muscle relaxant and anticonvulsant activity of 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a novel N-methyl-d-aspartate antagonist, in rodents

Non-competitive regulation of phencyclidine/σ-receptors by the N-methyl-d-aspartate receptor antagonist d-(−)-2-amino-5-phosphonovaleric acid

Antagonism of N-methyl-D-aspartate (NMDA) evoked increases in cerebellar cGMP and striatal ACh release by phencyclidine (PCP) receptor agonists: evidence for possible allosteric coupling of NMDA and PCP receptors.

TLDR
It is reported that phencyclidine receptor agonists demonstrated a noncompetitive antagonism of NMDA receptor agonist actions.

Unusual interactions of excitatory amino acid receptor agonists: α- and β-kainate antagonize motor responses to N-methyl-d-aspartate in rodents

Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.

TLDR
The results suggest that hypoglycemic neuronal damage is induced by NMDA receptor agonists, such as the excitatory amino acids or related compounds.

Anticonvulsant action of excitatory amino acid antagonists.

TLDR
Specific antagonists of excitation that is caused by amino acids provide a new class of anticonvulsant agents, and the most potent such compound was 2-amino-7-phosphonoheptanoic acid.

Anticonvulsant properties of phencyclidine-like drugs in mice.

Muscle relaxant action of excitatory amino acid antagonists

The behavioral effects of phencyclidines may be due to their blockade of potassium channels.

TLDR
It is suggested that the behavioral effects of PCP and m-amino-PCP, may be due to a block of K+ conductance and enhancement of transmitter release at central neurons.

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

TLDR
The results suggest that reduction of synaptic excitation mediated via NMA receptors contributes to the anaesthetic/analgesic properties of these two dissociative anaesthetics.