Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease.

@article{Forsberg2002ParadoxicalCO,
  title={Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease.},
  author={G{\"o}te Forsberg and Olle Hernell and Silvia Melgar and Anne C E Israelsson and Sten G. Hammarstr{\"o}m and Marie-Louise Hammarstr{\"o}m},
  journal={Gastroenterology},
  year={2002},
  volume={123 3},
  pages={667-78}
}
BACKGROUND & AIMS Specific T-lymphocyte reactions are central in the pathogenesis of celiac disease, an inflammatory small-bowel enteropathy caused by a permanent intolerance to gluten. To delineate local T-lymphocyte responses to gluten, the cytokine expression in jejunal T lymphocytes of pediatric celiac patients with active disease, i.e., untreated and gluten-challenged celiac patients, was determined and compared with that of treated, symptom-free celiac patients and controls. METHODS… CONTINUE READING
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