Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY.

Abstract

Mammalian transmembrane adenylyl cyclases synthesize a restricted plasmalemmal cAMP pool that is intensely endothelial barrier protective. Bacteria have devised mechanisms of transferring eukaryotic factor-dependent adenylyl cyclases into mammalian cells. Pseudomonas aeruginosa ExoY is one such enzyme that catalyzes cytosolic cAMP synthesis, with unknown… (More)

Topics

7 Figures and Tables

Cite this paper

@article{Sayner2004ParadoxicalCL, title={Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY.}, author={Sarah L. Sayner and Dara W. Frank and Judy King and Hairu Chen and John Vandewaa and Troy Stevens}, journal={Circulation research}, year={2004}, volume={95 2}, pages={196-203} }