Paradoxical block of parathormone secretion is mediated by increased activity of G alpha subunits.

@article{Quitterer2001ParadoxicalBO,
  title={Paradoxical block of parathormone secretion is mediated by increased activity of G alpha subunits.},
  author={Ursula Quitterer and Michaela Hoffmann and Marc Freichel and Martin J. Lohse},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 9},
  pages={6763-9}
}
The paradox of blunted parathormone (PTH) secretion in patients with severe hypomagnesemia has been known for more than 20 years, but the underlying mechanism is not deciphered. We determined the effect of low magnesium on in vitro PTH release and on the signals triggered by activation of the calcium-sensing receptor (CaSR). Analogous to the in vivo situation, PTH release from dispersed parathyroid cells was suppressed under low magnesium. In parallel, the two major signaling pathways… CONTINUE READING

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