Paradoxical augmentation of bradykinin-induced vasodilatation by xanthine/xanthine oxidase-derived free radicals in isolated guinea pig heart.

@article{Olszanecki2002ParadoxicalAO,
  title={Paradoxical augmentation of bradykinin-induced vasodilatation by xanthine/xanthine oxidase-derived free radicals in isolated guinea pig heart.},
  author={Rafał Olszanecki and Valery I. Kozlovski and Stefan Chłopicki and Ryszard Jerzy Gryglewski},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2002},
  volume={53 4 Pt 1},
  pages={689-99}
}
Increased generation of reactive oxygen species contribute to endothelial dysfunction in atherosclerosis, hypertension and heart failure. Recently, it was suggested that bursts of superoxide anions may inactivate endothelial surface-bound enzymes such as angiotensin converting enzyme (ACE). Here, we tested effects of xanthine/xanthine oxidase-derived superoxide anions on vascular responses and ACE activity in the isolated guinea pig heart. We analysed effects of intracoronary infusion of low… CONTINUE READING

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