Paradoxical anti-epileptic effects of a GluR5 agonist of kainate receptors.

@article{Khalilov2002ParadoxicalAE,
  title={Paradoxical anti-epileptic effects of a GluR5 agonist of kainate receptors.},
  author={Ilgam Khalilov and June C. Hirsch and Rosa Cossart and Yehezkel Ben-Ari},
  journal={Journal of neurophysiology},
  year={2002},
  volume={88 1},
  pages={523-7}
}
Kainate generates in adult hippocampal neurons a seizure but also a massive excitation of interneurons and a dramatic increase of the inhibitory drive that impinges on principal cells. This "overinhibition" is largely mediated by GluR5-containing kainate receptors that are enriched on interneurons. Here, using the neonatal intact hippocampus in vitro and the triple chamber, we first show that this mechanism is fully operative in neonatal neurons. We then report that application to one… CONTINUE READING

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Dual role of GABA in the neonatal rat hippocampus

  • I KHALILOV, V. DHZALA, Y BEN-ARI, R KHAZIPOV
  • Dev Neurosci
  • 1999
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