Paradoxical anti-TNF-associated TB worsening: Frequency and factors associated with IRIS.

@article{Rivoisy2016ParadoxicalAT,
  title={Paradoxical anti-TNF-associated TB worsening: Frequency and factors associated with IRIS.},
  author={Claire Rivoisy and Florence Tubach and Carine Roy and Nathalie Nicolas and Xavier Mariette and D Salmon and Olivier Lortholary and Anne Bourgarit},
  journal={Joint, bone, spine : revue du rhumatisme},
  year={2016},
  volume={83 2},
  pages={173-8}
}
OBJECTIVES Paradoxical tuberculosis (TB) worsening, an example of the immune reconstitution inflammatory syndrome (IRIS), is an increasing phenomenon now described in several settings, including anti-tumor necrosis factor (TNF) discontinuation during biotherapy-induced TB. To better recognize it, we analyzed the frequency and factors associated with anti-TNF-induced TB-IRIS. METHODS Case-control study on anti-TNF-associated TB patients. IRIS cases, defined with the following consensus… CONTINUE READING