Paradoxical and Bidirectional Drug Effects

@article{Smith2012ParadoxicalAB,
  title={Paradoxical and Bidirectional Drug Effects},
  author={Silas Smith and Manfred Hauben and Jeffrey K Aronson},
  journal={Drug Safety},
  year={2012},
  volume={35},
  pages={173-189}
}
AbstractA paradoxical drug reaction constitutes an outcome that is opposite from the outcome that would be expected from the drug’s known actions. There are three types: 1A paradoxical response in a condition for which the drug is being explicitly prescribed.2Paradoxical precipitation of a condition for which the drug is indicated, when the drug is being used for an alternative indication.3Effects that are paradoxical in relation to an aspect of the pharmacology of the drug but unrelated to the… CONTINUE READING

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