Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage. Case report.

  title={Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage. Case report.},
  author={Brent L. Clyde and Andrew D. Firlik and Anthony M. Kaufmann and M P Spearman and Howard Yonas},
  journal={Journal of neurosurgery},
  volume={84 4},
Reports of intraarterial papaverine infusion as treatment for cerebral vasospasm are few and documented complications are uncommon. The authors report the case of a patient with paradoxical aggravation of cerebral arterial narrowing during selective intraarterial papaverine infusion intended to treat vasospasm following aneurysmal subarachnoid hemorrhage (SAH). A 48-year-old man presented to the authors' service with symptomatic vasospasm 10 days after experiencing an SAH. The ruptured anterior… 

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Intra-Arterial Nimodipine Infusion for Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage

  • W. ChoH. Kang M.H. Han
  • Medicine
    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences
  • 2011
Nimodipine can be recommended as an effective and safe intra-arterial agent for the treatment of symptomatic vasospasm after aSAH and showed satisfactory outcomes.



Treatment of cerebral vasospasm with intra-arterial papaverine.

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Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage.

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Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage.

The successful treatment of cerebral vasospasm after subarachnoid hemorrhage with superselective intra-arterial infusion of papaverine hydrochloride and eight of 10 patients showed improvement in neurological function after the procedure.

Clinical vasospasm after subarachnoid hemorrhage: response to hypervolemic hemodilution and arterial hypertension.

Over the course of treatment, 60% of patients with clinical vasospasm had sustained improvement by at least 1 neurologic grade, 24% maintained a stable neurologic status, and 16% continued to worsen, while one patient rebled and died while on hypervolemic hemodilution therapy.

Intracranial pressure changes induced during papaverine infusion for treatment of vasospasm.

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Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage.

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Transient severe brain stem depression during intraarterial papaverine infusion for cerebral vasospasm.

A 63-year-old woman had severe, symptomatic cerebral vasospasm secondary to subarachnoid hemorrhage. We initiated simultaneous infusions of papaverine into her left vertebral and left internal