Paradoxical absence of nuclear inclusion in cerebellar Purkinje cells of hereditary ataxias linked to CAG expansion.

@article{Koyano2002ParadoxicalAO,
  title={Paradoxical absence of nuclear inclusion in cerebellar Purkinje cells of hereditary ataxias linked to CAG expansion.},
  author={Shigeru Koyano and Kiyoshi Iwabuchi and Saburo Yagishita and Yoshiyuki Kuroiwa and Toshiki Uchihara},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2002},
  volume={73 4},
  pages={450-2}
}
Degeneration of cerebellar cortex is one of the principal features of hereditary ataxias linked to expansion of CAG repeat. In an attempt to clarify possible correlation between neuronal depletion and neuronal intranuclear inclusions, both triggered by the pathological expansion of CAG repeat, cerebellar sections from SCA1, SCA2, SCA3, and DRPLA cases were immunostained with anti-ubiquitin or anti-expanded polyglutamine antibody (1C2) and were screened for the presence of neuronal intranuclear… CONTINUE READING

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