Paradoxical Relationship Between B-type Natriuretic Peptide and Pulmonary Vascular Resistance in Patients with Ventricular Septal Defect and Concomitant Severe Pulmonary Hypertension

@article{Toyono2007ParadoxicalRB,
  title={Paradoxical Relationship Between B-type Natriuretic Peptide and Pulmonary Vascular Resistance in Patients with Ventricular Septal Defect and Concomitant Severe Pulmonary Hypertension},
  author={Manatomo Toyono and Kenji Harada and Masamichi Tamura and Mieko Aoki-Okazaki and Shunsuke Shimada and Jun Oyamada and Goro Takada},
  journal={Pediatric Cardiology},
  year={2007},
  volume={29},
  pages={65-69}
}
B-type natriuretic peptide (BNP) reflects volume overload on left ventricle and pulmonary hypertension (PH) in patients with ventricular septal defect (VSD). Pulmonary vascular resistance (PVR) has been reported to correlate positively with BNP in VSD patients with various degrees of PH. We aimed to investigate the relationship between PVR and BNP in VSD patients with severe PH. We examined 24 subjects with VSD concomitant severe PH aged from 2 months to 17 years (median: 4 months). The ratio… CONTINUE READING