Paradoxical Reactions to Benzodiazepines: Literature Review and Treatment Options

@article{Mancuso2004ParadoxicalRT,
  title={Paradoxical Reactions to Benzodiazepines: Literature Review and Treatment Options},
  author={C. Mancuso and Maria G. Tanzi and M. Gabay},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2004},
  volume={24}
}
Benzodiazepines frequently are administered to patients to induce sedation. Paradoxical reactions to benzodiazepines, characterized by increased talkativeness, emotional release, excitement, and excessive movement, are relatively uncommon and occur in less than 1% of patients. The exact mechanism of paradoxical reactions remains unclear. Most cases are idiosyncratic; however, some evidence suggests that these reactions may occur secondary to a genetic link, history of alcohol abuse, or… Expand

Paper Mentions

Interventional Clinical Trial
This study is to compare propofol vs. midazolam with propofol for sedative endoscopy in patients with previous paradoxical reaction to midazolam. Patients who meet eligibility… Expand
ConditionsEndoscopy, Sedation
InterventionDrug
Paradoxical reaction following administration of a benzodiazepine.
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Successful flumazenil reversal of paradoxical reaction to midazolam in a child.
Paradoxical Reaction to Midazolam in Preterm Neonates: A Case Series
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Paradoxical reaction to midazolam in children
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  • Korean journal of anesthesiology
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Benzodiazepines in epilepsy: pharmacology and pharmacokinetics
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Flumazenil Reverses Paradoxical Reaction to Midazolam in a Child
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