Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus.

@article{Ravassard2009ParadoxicalS,
  title={Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus.},
  author={Pascal M Ravassard and Bastien Pachoud and Jean-Christophe Comte and Camila Mejia-Perez and C{\'e}line Scot{\'e}-Blachon and Nadine Gay and Bruno Claustrat and Monique Touret and Pierre-Herv{\'e} Luppi and Paul Antoine Salin},
  journal={Sleep},
  year={2009},
  volume={32 2},
  pages={227-40}
}
STUDY OBJECTIVES It has been shown that wake (W) and slow wave sleep (SWS) modulate synaptic transmission in neocortical projections. However the impact of paradoxical sleep (PS) quantities on synaptic transmission remains unknown. We examined whether PS modulated the excitatory transmission and expression of glutamate receptor subtypes and phosphorylated extracellular signal-regulated kinases (p-ERK1/2). DESIGN PS deprivation (PSD) was carried out with the multiple platforms method on adult… CONTINUE READING