Paradoxic Activation of the Renin-Angiotensin System in Twin-Twin Transfusion Syndrome: An Explanation for Cardiovascular Disturbances in the Recipient

@article{MahieuCaputo2005ParadoxicAO,
  title={Paradoxic Activation of the Renin-Angiotensin System in Twin-Twin Transfusion Syndrome: An Explanation for Cardiovascular Disturbances in the Recipient},
  author={D. Mahieu‐Caputo and A. Meulemans and J. Martinovic and M. Gubler and A. Delezoide and F. Muller and P. Mad{\'e}l{\'e}nat and N. Fisk and M. Dommergues},
  journal={Pediatric Research},
  year={2005},
  volume={58},
  pages={685-688}
}
Despite advances in treatment, twin-to-twin transfusion syndrome (TTTS) still carries a high risk for perinatal mortality and morbidity. Simple blood transfer from the donor to the recipient twin cannot explain all of the features of this disease, in particular the recipient's hypertensive cardiomyopathy. We report a case in which TTTS resulted in preterm delivery with early neonatal death of both twins, allowing assessment of the renin angiotensin system (RAS) status of each fetus, both by… Expand
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