Paradoxes of the replication of picornaviral genomes.

  title={Paradoxes of the replication of picornaviral genomes.},
  author={Vadim I Agol and Aniko Paul and Eckard J Wimmer},
  journal={Virus research},
  volume={62 2},
A wealth of experimental data on the mechanism of the picornavirus genome replication has accumulated. Not infrequently, however, conclusions derived from these data appear to contradict each other. On the one hand, initiation of a complementary RNA strand can be demonstrated to occur in a solution containing only the poliovirus RNA polymerase, VPg, uridine triphosphate, poly(A) template and appropriate ions. On the other hand, convincing experiments suggest that efficient initiation of a viral… CONTINUE READING
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