Paradigms of protein degradation by the proteasome.

@article{Inobe2014ParadigmsOP,
  title={Paradigms of protein degradation by the proteasome.},
  author={Tomonao Inobe and Andreas Matouschek},
  journal={Current opinion in structural biology},
  year={2014},
  volume={24},
  pages={156-64}
}
The proteasome is the main proteolytic machine in the cytosol and nucleus of eukaryotic cells where it degrades hundreds of regulatory proteins, removes damaged proteins, and produces peptides that are presented by MHC complexes. New structures of the proteasome particle show how its subunits are arranged and provide insights into how the proteasome is regulated. Proteins are targeted to the proteasome by tags composed of several ubiquitin moieties. The structure of the tags tunes the order in… CONTINUE READING
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