Paradigms of protein degradation by the proteasome.

  title={Paradigms of protein degradation by the proteasome.},
  author={Tomonao Inobe and Andreas Matouschek},
  journal={Current opinion in structural biology},
The proteasome is the main proteolytic machine in the cytosol and nucleus of eukaryotic cells where it degrades hundreds of regulatory proteins, removes damaged proteins, and produces peptides that are presented by MHC complexes. New structures of the proteasome particle show how its subunits are arranged and provide insights into how the proteasome is regulated. Proteins are targeted to the proteasome by tags composed of several ubiquitin moieties. The structure of the tags tunes the order in… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 37 extracted citations

Regulation of base excision repair proteins by ubiquitylation.

Experimental cell research • 2014
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 88 references

AAA+ proteases: ATP-fueled machines of protein destruction.

Annual review of biochemistry • 2011
View 3 Excerpts
Highly Influenced

Recognition and processing of ubiquitin-protein conjugates by the proteasome.

Annual review of biochemistry • 2009
View 4 Excerpts
Highly Influenced

Coffino P: Ubiquitin-independent proteasomal degradation

J Erales
Biochim Biophys Acta • 2014
View 1 Excerpt

This paper describes a novel mechanism by which ubiquitin independent degradation by the 20 S proteasome may be regulated and linked to the metabolic state of the cell

KB Sylvestersen, C Young, ML Nielsen
Current Opinion in Structural Biology • 2014

Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase.

Proceedings of the National Academy of Sciences of the United States of America • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…