Paradigms in the structural biology of the mitogenic ternary complex FGF:FGFR:heparin.

Abstract

The main achievements regarding the molecular interaction involving fibroblast growth factors (FGFs), canonical receptors (FGFRs) and the glycosaminoglycans (GAGs) heparan sulfate (HS)/heparin (Hp) are overviewed. Despite the recent works concerning the subject, conflicting paradigms in the structural biology of the resultant ternary complex FGF:FGFR:HS/Hp… (More)
DOI: 10.1016/j.biochi.2016.05.017

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