Paradigm shifts in heart-failure therapy--a timeline.

@article{Sacks2014ParadigmSI,
  title={Paradigm shifts in heart-failure therapy--a timeline.},
  author={Chana A Sacks and John Adams Jarcho and Gregory D. Curfman},
  journal={The New England journal of medicine},
  year={2014},
  volume={371 11},
  pages={989-91}
}
W the publication of the PARADIGM-HF trial in the Journal (pages 993–1004) we may be entering a new era of treatment for heart failure with reduced ejection fraction. To provide a historical perspective on the beginning of this new epoch, we constructed an interactive timeline (available with the full text of this article at NEJM.org) of 26 randomized, controlled trials in heart-failure treatment that have been published in the Journal since 1986. Each of these articles — some demonstrating… CONTINUE READING
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