Paracrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironment

@article{Lubik2017ParacrineSH,
  title={Paracrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironment},
  author={Amy Lubik and Mannan Nouri and Sarah Mai Truong and Mazyar Ghaffari and Hans H. Adomat and Eva Corey and Michael E. Cox and Na Li and Emma S. Tomlinson Guns and Parvin Yenki and Steven Pham and Ralph Buttyan},
  journal={International Journal of Cancer},
  year={2017},
  volume={140}
}
Despite the substantial benefit of androgen deprivation therapy (ADT) for metastatic prostate cancer, patients often progress to castration‐resistant disease (CRPC) that is more difficult to treat. CRPC is associated with renewed androgen receptor activity in tumor cells and restoration of tumor androgen levels through acquired intratumoral steroidogenesis (AIS). Although prostate cancer (PCa) cells have been shown to have steroidogenic capability in vitro, we previously found that benign… 
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