Paracrine signalling events in embryonic stem cell renewal mediated by affinity targeted nanoparticles.

@article{Corradetti2012ParacrineSE,
  title={Paracrine signalling events in embryonic stem cell renewal mediated by affinity targeted nanoparticles.},
  author={Bruna Corradetti and P Freile and Steve C Pells and Pierre Bagnaninchi and Jason Park and Tarek M. Fahmy and P A De Sousa},
  journal={Biomaterials},
  year={2012},
  volume={33 28},
  pages={6634-43}
}
Stem cell growth and differentiation is controlled by intrinsic and extrinsic factors. The latter includes growth factors, which are conventionally supplied in vitro in media exchanged daily. Here, we illustrate the use of affinity targeted biodegradable nanoparticles to mediate paracrine stimulation as an alternative approach to sustain the growth and pluripotency of mouse embryonic stem cells. Leukaemia Inhibitory Factor (LIF) was encapsulated in biodegradable nanoparticles and targeted to… CONTINUE READING
10 Citations
39 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Similar Papers

Loading similar papers…