Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells.

@article{Yamada2012ParacrineRA,
  title={Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells.},
  author={Tadaaki Yamada and Shinji Takeuchi and Junya Nakade and Kenji Kita and Takayuki Nakagawa and Shigeki Nanjo and Takahiro Nakamura and Kunio Matsumoto and Manabu Soda and Hiroyuki Mano and Toshimitsu Uenaka and Seiji Yano},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 13},
  pages={3592-602}
}
PURPOSE Cancer cell microenvironments, including host cells, can critically affect cancer cell behaviors, including drug sensitivity. Although crizotinib, a dual tyrosine kinase inhibitor (TKI) of ALK and Met, shows dramatic effect against EML4-ALK lung cancer cells, these cells can acquire resistance to crizotinib by several mechanisms, including ALK amplification and gatekeeper mutation. We determined whether microenvironmental factors trigger ALK inhibitor resistance in EML4-ALK lung cancer… CONTINUE READING
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