Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6.

@article{Klein1989ParacrineRT,
  title={Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6.},
  author={Bernard Klein and X G Zhang and Maud Jourdan and J. Content and Fr{\'e}d{\'e}ric A. Houssiau and L Aarden and Marc Piechaczyk and R{\'e}gis Bataille},
  journal={Blood},
  year={1989},
  volume={73 2},
  pages={517-26}
}
To explore the mechanisms involved in the pathogenesis of human multiple myeloma (MM), we investigated the potential role of interleukin-6 (IL-6), a B-cell differentiation factor in humans, and a growth factor for rat/mouse heterohybridomas and murine plasmacytomas. Using a heterohybridoma assay, we found that two well-documented human myeloma cell lines, RPMI 8226 and U266, did not secrete IL-6 and did not express RNA messengers for IL-6. Neutralizing antibodies to IL-6 did not inhibit their… CONTINUE READING
233 Citations
65 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 233 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Olive D , Van Snick J : Synergistic activation of human T - cells by interleukin 1 and interleukin 6

  • FA Houssiau, PG Coulie
  • Eur J Immunol
  • 1988

Similar Papers

Loading similar papers…