Paracrine mediators of mechanotransduction in lung development.

  title={Paracrine mediators of mechanotransduction in lung development.},
  author={John Steven Torday and Juan Sanchez-Esteban and Lewis P. Rubin},
  journal={The American journal of the medical sciences},
  volume={316 3},
The process of normal fetal lung development is dependent on "mild" tissue distension (approximately 3 mm Hg) by fluid, resulting in the production of pulmonary surfactant which is necessary for survival at the time of birth. The mechanical "stretching" of lung tissue triggers a cellular differentiation cycle, in part by stimulating the expression and production of cell phenotype-specific soluble cytokines. Pulmonary cytokines regulate differentiation and metabolic function of neighboring cells… CONTINUE READING


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