Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes

@inproceedings{Platas2016ParacrineEO,
  title={Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes},
  author={Julia Platas and Maria Isabel Guill{\'e}n and Mar{\'i}a Dolores P{\'e}rez del Caz and Francisco Gomar and Miguel Angel Castej{\'o}n and Vicente Mirabet and Maria Jos{\'e} Alcaraz},
  booktitle={Aging},
  year={2016}
}
Aging and exposure to stress would determine the chondrocyte phenotype in osteoarthritis (OA). In particular, chronic inflammation may contribute to stress-induced senescence of chondrocytes and cartilage degeneration during OA progression. Recent studies have shown that adipose-derived mesenchymal stem cells exert paracrine effects protecting against degenerative changes in chondrocytes. We have investigated whether the conditioned medium (CM) from adipose-derived mesenchymal stem cells may… CONTINUE READING
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Osteoarthritis Cartilage

  • Osteoarthritis Cartilage
  • 2015

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