Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury.

@article{Zuo2012ParacrineEO,
  title={Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury.},
  author={Shi Zuo and Walter K. Jones and Hongxia Li and Zhisong He and Zeeshan Pasha and Yueting Yang and Yigang Wang and Guo-Chang Fan and Muhammad Ashraf and Meifeng Xu},
  journal={Stem cells and development},
  year={2012},
  volume={21 4},
  pages={598-608}
}
Our previous studies have suggested that transduction of Wnt11 directly increases bone marrow-derived mesenchymal stem cells (MSCs) differentiation into cardiac phenotypes. In this study, we investigated whether Wnt11 enhances MSC-mediated cardioprotection via paracrine fashion after acute ischemia. MSCs were harvested from male rat bone marrow and transduced with Wnt11 (MSC(Wnt11)). An acute myocardial infarction model in rats was developed by ligation of the left anterior descending coronary… CONTINUE READING
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