Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the ApcMin/+ mouse model of intestinal tumorigenesis

@inproceedings{Hull2017ParacrineCA,
  title={Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the ApcMin/+ mouse model of intestinal tumorigenesis},
  author={Mark A Hull and Richard J. Cuthbert and C W Stanley Ko and Daniel J Scott and Elizabeth J. Cartwright and Gillian Hawcroft and Sarah L Perry and Nicola Ingram and Ian M. Carr and Alexander F. Markham and Constanze Bonifer and Patricia Louise Coletta},
  booktitle={Scientific Reports},
  year={2017}
}
Genetic deletion or pharmacological inhibition of cyclooxygenase (COX)-2 abrogates intestinal adenoma development at early stages of colorectal carcinogenesis. COX-2 is localised to stromal cells (predominantly macrophages) in human and mouse intestinal adenomas. Therefore, we tested the hypothesis that paracrine Cox-2-mediated signalling from macrophages… CONTINUE READING