Paracrine control of myoblast proliferation and differentiation by fibroblasts.

  title={Paracrine control of myoblast proliferation and differentiation by fibroblasts.},
  author={Lebris S Quinn and Leelee Ong and R A Roeder},
  journal={Developmental biology},
  volume={140 1},
Double-muscling (DM) is a hereditary (apparently single-gene) skeletal muscle hyperplasia which occurs in beef cattle. In order to investigate the cellular basis of this phenotype, cell cultures from developing muscle tissue of normal and DM fetal calves were studied. In cultures composed of both myogenic cells and nonmyogenic, fibroblast-like cells, DM myoblasts exhibited a prolonged proliferative phase. This resulted in delayed, but increased production of fused myotubes in the DM cultures… CONTINUE READING
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