Paracrine control of gastric epithelial cell growth in culture by transforming growth factor-alpha.

@article{Chen1993ParacrineCO,
  title={Paracrine control of gastric epithelial cell growth in culture by transforming growth factor-alpha.},
  author={Monica Chi-Yun Chen and Anh Tuyet Lee and William Karnes and D Avedian and Mitchell Martin and J M Sorvillo and Andrew H. Soll},
  journal={The American journal of physiology},
  year={1993},
  volume={264 2 Pt 1},
  pages={G390-6}
}
Studying primary cultures of replicating canine oxyntic mucosal cells, we found evidence for modulation of cell growth by endogenous factors. [3H]thymidine incorporation into DNA was rapid with cells cultured in medium free of serum or added growth factors, and growth rates of these cultures were markedly dependent on plating density, indicating mitogenic control by soluble endogenous growth factors. Data indicated that endogenous transforming growth factor-alpha (TGF-alpha) exerted mitogenic… CONTINUE READING

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